MIMM 214 Lecture Notes - Lecture 11: Mhc Class I, Calnexin, Antigen
5 Jan 2019
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Document Summary
Cell loads the mhc molecule as it is made in the er. Calnexin prevents molecule from falling apart during assembly (chaperon) Other chaperons will help stabilize until peptide binding. Cytosolic antigenic peptides are degraded by proteasomes into fragments that are pumped into the er by tap pump. A peptide binds the mhc class i molecules. The mhc class i molecule is released from the chaperons and exported to the cell membrane in a phagolysosome. Tap pump complex delivers the antigenic peptides from the cytosol into the er to bind the mhc molecules. Immunoevasins: a favourite strategy of virus to evade the. Some viruses interfere with mhc class i presentation pathway by: Blocking peptide entry into the er by inhibiting tap. Interfere directly on the cell surface i. e. murine cmv. Antigen is taken up form the extracellular space into intracellular phagolysosome. In early endosomes of neutral ph, endosomal proteases are inactive.
