MIMM 214 Lecture Notes - Lecture 2: Immunodeficiency, Lymphadenopathy, Mucosa-Associated Lymphoid Tissue
5 Jan 2019
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Document Summary
Evolutionary selective pressure of immune system: protect humans from infections (natural selection drives coevolution) Collection of organs, tissues, cells and molecules that coordinately work to protect from infection (not discrete) Bone marrow: contain progenitors that become immune cells" Proportionally bigger earlier in life, fades out as we age. Lymph nodes: regional collection of immune cells. Malt: mucosal associated lymphoid tissue in gi, gut, skin, peyer"s patches, tonsil, adenoid. Golden rule of operating principle: differentiate from what is self and what is not. The 4 classes of pathogens can be consolidated into 2 types of pathogenicity: extracellular and intracellular. The ability of the immune system to detect extracellular and intracellular is essential. If immune approach makes wrong choice, the disease wins. Any molecule that can trigger an immune response. It can be a protein (most common), nucleic acid, polysaccharide, lipid, organic chemicals, drugs. Most ags are foreign to the body = non-self.
