MIMM 214 Lecture Notes - Lecture 33: Lymph Node, Hematopoietic Stem Cell Transplantation, Mhc Class Ii
4 Apr 2017
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Lymphocyte development, negative regulation & immune tolerance (module 4) Safe: must not cause illness or death. Protective: must protect against illness upon exposure to pathogen. Give sustained protection: protection must last several years. Induces neutralizing ab and specific cellular immunity: some pathogens, e. g. polio virus, infect cells that cannot be replaced (e. g, some pathogens, e. g. polio virus, infect cells that cannot be replaced (e. g. neurons). Neutralizing antibody is essential to prevent infection of such cells. Induces protective t cells: some pathogens, particularly intracellular, are more effectively dealt with by cell-mediated responses. Practical considerations: low cost per dose, biological stability, route of administration/ ease of administration, few side effects. This cartoon illustrates the main take home messages of different types of vaccines. Classic approach to vaccines is to produce an attenuated organism this is a live organism/virus/bacteria that has been attenuated it is no longer pathogenic/disease-causing: e. g. vaccines for measles, mumps, rubella, oral polio, varicella.
