MIMM 214 Lecture 3: Overview of the Immune System II
7 Feb 2017
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Document Summary
Innate response: breach of epithelial cell layer, cells underneath epithelium that are able to detect breaches, pathogen recognition. There are certain markers that are used to recognize pathogens. Sensor cells express pattern recognition receptors (prrs: provide an initial discrimination between self and non-self, recognize broad categories of molecules that are commonly found in pathogens (pathogen associated. Molecular patterns - pamps: not very specific, pamps are on our cells (self) Pathogen detection leads to activation of sensor cells: dendritic cells pay key role, detect pathogens using receptors (prrs, pattern recognition occurs at the site of infection. Sensor cells induce an inflammatory response by producing mediators such as chemokines and cytokines: redness, heat, swelling, and pain are hallmarks of inflammation. Increases permeability of vessels to bring in more inflammatory cells to the local site of infection. Dendritic cells link innate and adaptive immunity: dcs travel from site of infection to local lymphoid tissue.
