MIMM 214 Lecture Notes - Lecture 5: Phagosome, Neutrophil, Basophil
4 Feb 2017
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Document Summary
If you refer to the final diagram from the previous lecture, you"ll see that it was only around day 6 that we started to see antibody. Complement is part of innate immunity but provides link to adaptive: humoral immunity. Complement proteins are mostly produced by liver and then go into circulation. Set off a chain reaction that helps to amplify inflammation and clear pathogens. Increasing vascular permeability and chemotaxis of immune cells to site of infection: destroying pathogen cell membranes. Increasing recognition of pathogens and facilitating phagocytosis (opsonisation) Opsonisation: the coating of the surface of a pathogen by antibody and/or complement that makes it more easily ingested by phagocytes. Activated in 3 ways these act in cascades: classical pathway, alternative pathway, lectin pathway. Once activated, become proteases that can cleave other proteins. Acting as a cascade: proteolytic cleavage generating two fragments: Identified by the letter a after the name (e. g. c5a) Results from a larger called c4, c5, etc.
