MIMM 211 Lecture Notes - Lecture 16: Trichuris, Helminths, Ascaris
14 Nov 2016
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Document Summary
Ibd soil transmitted helminth red blood cell visceral leishmaniasis cutaneous leishmaniasis tuberculosis gastro-intestinal tract inflammatory bowel disease. Intro: parasites vs bac vs viruses: parasites have a nucleus bc eukaryotic, ex. In dev countries, no shoes bc roads are muddy, so easy to penetrate foot skin: so poor sanitary conditions, children in developing countries are most vulnerable; they often have all 3. Parasites are stealing nutrients from the child: cause malnutrition, growth stunting, cogni/learning defects, weaken immune response to other infections like malaria, tb, hiv, only infect humans. Inhibit helminth tubule polymerization, so paralyse the parasite every year. Lf sits in lymph nodes and grow to adult there, blocks lymph fluid to cause swelling: cause elephantiasis, transmission by mosquito, not soil. Hygiene hypothesis: early childhood exposure to infections/parasites is required for development of a solid immune system, helminth infections common in dev countries, autoimmune/allergies common in first world countries, ex. Host-parasite interactions and immunity: parasites as a treatment for auto-
