INDS 111 Lecture Notes - Lecture 35: Veterinary Medicine, Pharmacogenomics, Pharmacokinetics

• School: McGill University
• Department: Interndisciplinary Studies
• Course: INDS 111
• Professor: Anne Andermann

Document Summary

The use of medications for treatment and prevention, and issues of non-compliance. Pharmacology: all aspects of drugs and their interactions with living organisms. The term drug includes all substances with effects on living cells. Considers the: physical and chemical properties of drugs their biochemical and physiological effects their mechanisms of action pharmacokinetics therapeutic and other uses. Drug uses: therapeutics, diagnosis, prophylaxis, veterinary medicine, horticulture. Huge variability in patient responses to drugs: age, gender, specific physiological states, renal or hepatic function, concurrent drugs, concurrent diseases, adverse or allergic reactions to drugs, pharmacogenetic phenotype (polymorphisns), pharmacokinetics, pharmacodynamics. Future of pharmacogenomics: genome wide approach versus candidate gene approach, thousands of snps, thousands of patients, replication studies, sophisticated databases housing pharmacogenomic information, drug selection and dosing algorithms incorporating non-genetic and genetic information, point of care genetic testing. Of the known functionally important mutations only a limited number are tested. Phenotype studied is only in part caused by candidate gene.