BIOC 311 Lecture Notes - Lecture 17: Rotation Around A Fixed Axis, Hydroxyl Radical, Adenine

• School: McGill University
• Department: Biochemistry
• Course: BIOC 311
• Professor: Julie St- Pierre

Document Summary

Basal (through lipid bilayer), induced uncoupling mediated by uncoupling proteins (ucp1) A redox centre that accepts simultaneously a proton and electrons from matrix. Second, reoxidation of this redox centre by the next centre involves release of h+ in cytosol and transfers of electron back into the matrix. For this mechanism to occur, the first carrier has to contain more h atoms in its reduced state than its oxidized state. The second carrier is a pure electron carrier with no different in h content between its reduced and oxidized states. Difficulty: proton and electron carriers do no alternate with pure electron carriers => Thus it cannot be only way you get proton transfer. Proton binds to aa side chain in matrix. Reduction (when e comes from nadh) will cause a conformational change that will decrease pka of aa side chain and expose them to cytosol where proton dissociate (proton releases in intermembrane space).