BIOC 311 Lecture Notes - Lecture 15: Reactive Oxygen Species, Stoichiometry, Membrane Potential

• School: McGill University
• Department: Biochemistry
• Course: BIOC 311
• Professor: Julie St- Pierre

Document Summary

Complexes of etc embedded in imm = 80% proteins (high protein density), high surface area. Energy from oxidation of fas, aas and carbohydrates made available within mitochondrion as reducing equivalents (nadh, fadh2). Etc collects and transports reducing equivalents directing them to their final reaction with oxygen to make water. Generation of proton gradient (pumping of protons by complexes from matrix to intermembrane space) used to drives atp synthesis by atp synthase. Consists of a series of redox centres bound to proteins located in imm in addition to coenzyme q and cytochrome c (shuttle between complexes 3 and 4). (electron carriers that are mobile, not fixed) The redox centres are arranged sequentially in order of increasing standard reduction potential (srp. Oxygen has greatest capacity to accept electrons, last electron acceptor. The reduced member of one redox couple is oxidized member of the next redox complex.