BIOC 311 Lecture Notes - Lecture 25: Ribose 5-Phosphate, Phosphoribosyl Pyrophosphate, Uridine Monophosphate

• School: McGill University
• Department: Biochemistry
• Course: BIOC 311
• Professor: Maxime Denis

Document Summary

Nucleotide metabolism: where most of the nucleotides within our cells are acquired exogenously (through the diet) via the salvage pathway. Nucleotide synthesis from starting materials (e. g. salvage pathway. The 2 de novo pathways: purine pathway, requires prpp, glutamine, aspartate, co2, glycine, formate in order to produce imp, pyrimidine pathway, requires prpp, glutamine, aspartate, co2 in order to make ump. Nucleotides: made up of a base (the aromatic part), ribose sugar, and >1 phosphate. Nucleoside: contains only the base and ribose portion, 0 phosphates. The blue represents the salvage pathway (synthesis up, degradation down) The bottom layer of the cube represents the bases (the foundation) The middle layer of the cube are the nucleosides. The top layer of the cube are diphosphates these are what all go in to making imp for amp/gtp production. Below the foundation, you see uric acid this is what nucleotides get degraded to. This is more abstract because these nucleotides are selective for either.