BIOC 212 Lecture Notes - Lecture 12: Adherens Junction, Tight Junction, Intermediate Filament
29 Feb 2020
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Occuliding junctions: seal cells together, does not allow leaking. Anchoring junctions: anchors to actin filaments in the cells. Em wavelength = 0. 004 nm vs 1nm for lm. Basolateral surface = contact with lumen (blood) Tight junctions: seal cells together, does not allow leaking. Analysis: use tracer molecules : made of lanthanum (element with high atomic number) if it. Proteins: n and c term are in cytosol passes: no tight junction. Mutation of claudine16 = loss of mg in urine. Zo proteins : anchor tight junction to actin filaments. Cell-cell anchoring junctions: common protein = cadherin. Adherens junctions connected to actin filament. Tm proteins: cadherins homodimers btw cells. Anchor: catenins , vinculin and alpha-actinin link. High ca (has to be low in cells to be easily regulated) Important in folding of epithelial sheet to form epithelial tube in early development . Cadherins to actin adherens junction make contraction pinch off. Tm proteins: desmoglein and desmocollin (members of cadherin family)
