ANAT 416 Lecture Notes - Lecture 15: Retinal Pigment Epithelium, Stem-Cell Therapy, Macular Degeneration
3 Jun 2020
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Feb 28 // lec 15 // eye dev and regen 1 // m cayouette. Ve feedback by ganglionic cells to prevent production of too many ganglionic cells. Temporal identity factors like hunchback (droso), ikaros (mouse) Mice: embryonic day 9. 5 postnatal day 10 (born with eyes closed) Optic vesicle -> optic cup through folding, sequence of inductive events between ectoderm and neuroepithelium. Rpe retinal pigment epithelium (neural origin but are not neurons) The lens placode = non-neural, pinch off of surface ectoderm. Macula, which has high concentration of cones (high acuity daylight vision) Fovea within macula extremely rich in cones, where light from the lens focuses. Losing very few of those cells can have large impact macular degeneration. Retinal progenitor cells make up the retina (don"t call them retinal sc bc they don"t self-renew forever) Can proliferate and self-renew for a limited amount of time, during embryonic stages of development. Eventually undergo terminal division, producing two neurons, ending the lineage.
