ANAT 321 Lecture Notes - Lecture 20: Proprioception, Lesion, Cerebellum
20 Dec 2017
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*inferior olive = get converging input from cortex & sc send output as climbing fibers. Grey matter in brainstem b/w medulla & pons. Make excitatory (+) synapses directly with: purkinje cells & b) deep nuclei neurons. * climbing fibers = send collateral projections to deep nuclei. 1- climbing fibers excitatory (+) synapse with a) purkinje cells & b) deep nuclei. 2- climbing fibers wrap around thick dendrites of purkinje cells in molecular layer. * close to purkinje cell bodies so powerful synapse. 3- a) purkinje cells make inhibitory (-) synapses on b) deep nuclei. Receives excitatory (+) input only 1 single climbing fiber. *purkinje cells = each receives powerful excitatory (+) input from 1 single climbing fiber. Enough to activate purkinje cells to fire ap. Activated (+) purkinje cells = regular slow complex spikes driven by climbing fiber input. Complex spikes at regular intervals [1-3 hz] so not changed much.
