ANAT 262 Lecture Notes - Myosin Light-Chain Kinase, Rho-Associated Protein Kinase, Coiled Coil

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plumcod665

21 Aug 2012

School

McGill University

Department

Anatomy & Cell Biology

Course

ANAT 262

Professor

John Presley

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Document Summary

Intermediate filaments derive their name from the fact that their diameter (10nm) is intermediate to af and mts. Ifs can be found in the nucleus and cytoplasm. Nuclear ifs are composed of lamins and form the 2d meshwork underlying the nuclear envelope. Non-polar, static structures which give cells rigidity, very stable (long turnover time) No motor proteins (not polar), primarily give structure (not much happens with them over time - not as dynamic as mt or af) Types i (acidic) and ii (basic) - keratins are co-expressed in all types of epithelial cells (these are the largest classes) Keratin filaments (found in the skin) are heteropolymers containing equal amounts of type i and type ii keratin. This large family of proteins are involved in forming hair, nails, and toughening of the skin. Also found in desmosomes (strongest cellular junction) Type iii ifps are expressed in different cell types.

Related Questions

Answer the following true or false

a. The presence of keratins in a sheet-like organization is hallmark of epithelial cells.

b.Compare to other filaments, only intermediate filaments require protein contact between heterodimers of individual filament proteins

c.The type III protein desmin is expressed in a wide range of tissue types, while vimentin is expressed primarily in muscle cells; both proteins co-express with GFAP in the nucleus

d.Compare to other filaments, only intermediate filament do not require ATP for growth.

e.Keratins are expressed in and around specialized structures such as hair or nails.

Answer The Following A-F

A.One of the earliest events in the assembly of intermediate filaments is the joining of two intermediate filament proteins to form a dimer linked through a coiled coil. What structural property of intermediate filament proteins allows this to occur?

B.Which two types of genes constitute most of the intermediate filament genes?

C.Compare the intermediate filaments desmin and vimentin?

D.What are the similar and original features that distinguishes type V intermediate filaments from the other four types of intermediate filaments?

E.What are the properties of lamins?

F.The most common type of intermediate filament associated proteins are _________. What are their roles?

PLEASE I NEED HELP!!!

1. How does the extracellular matrix affect a cell that it surrounds? (Select all that apply.)

	The cell's shape depends in part on the structure and composition of the extracellular matrix.
	The genes that the cell expresses depend in part on the types of proteins in the extracellular matrix.
	The size that the cell grows to depends in part on the polysaccharides in the extracellular matrix.
	The extracellular matrix has no effect on the cells that it surrounds.
	All of these choices are correct.

2. Which of the following enable(s) the movement of cells?

	microtubules
	microfilaments
	intermediate filaments
	microtubules and microfilaments
	microfilaments and intermediate filaments

3. Microtubules increase in length:

	more quickly at one end than the other.
	by growing outward from the centrosome.
	in cycles, following rapid depolymerization.
	if free tubulin dimers are available.
	All of these choices are correct.

4. Dynamic instability is the rapid assembly and disassembly of:

	microfilaments.
	intermediate filaments.
	microtubules.
	both microfilaments and microtubules.

5. Which one of the following is a characteristic shared by integrins and cadherins?

	Both are peripheral membrane proteins.
	Both facilitate the adhesion of cells to extracellular matrix proteins.
	Both are present in adherens junctions, desmosomes, and hemidesmosomes.
	The cytoplasmic domains of both proteins are connected to the cytoskeleton.

6. Cadherin is an example of a(n):

	motor protein.
	intermediate filament protein.
	cell adhesion molecule.
	extracellular matrix protein.

7. Which is the CORRECT order from lesser to greater complexity for the following?

	organs, tissues, cells
	cells, tissues, organs
	tissues, organs, cells
	cells, organs, tissues

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ANAT 262 Lecture Notes - Myosin Light-Chain Kinase, Rho-Associated Protein Kinase, Coiled Coil

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