ANAT 212 Lecture Notes - Lecture 16: Triple Helix, Hydroxylysine, Fibril
30 Mar 2020
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Document Summary
There are 42 collagen genes in humans given rise to 27 different types of collagens with different function. 3 chains form a collagen triple helix. There are fibril-forming collagens and sheet forming collagens. Collagen can exist as homotrimers (the same chains form the triple helix) or heterodimers. The chain is a left winding helix (if we tilt it) Repeating structure (glycine followed by an x and y repeatedly) gly-x-y. When 3 of the chain goes together, they form a right-handed helix (if we tilt it and go. In the x position, it is often proline and in the y position, it is often along one chain) It has an important function in this triple helix since it can be hydroxylated. Look at each of the chains ( color). We can see that glycine is always in the center and the chains circle around.
