ANAT 212 Lecture Notes - Lecture 13: Plakoglobin, Desmoglein, Coiled Coil
30 Mar 2020
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Desmosome anchor cells (e. g. epithelial cells (like keratinocyte, skin cells) endothelial cells (blood lining cells )). Em of a desmosome: we can see 2 plasma membranes, and we can see 3 cells. We can see fibers running into a dense plaque (they don"t end at the plaque, they touch there but they re- enter back into the interior of the cell). The intermediate filaments (cytoskeleton elements) don"t end at this type of anchoring junctions. The intermediate filaments can be keratin (in epithelial cells, skin cells) or desmin (in heart cells) The proteins that connect with each other"s are the cadherins family proteins: cadherins connect the 2 cells in the desmosome, 2 important cadherins are: desmoglein and desmocollin. There is 2 important proteins in the dense plaque: plakoglobin and desmoplakins. Human disease pemphigus vulgaris it is a skin blistering disease. This is caused by patients developing auto antibodies against desmoglein (a cadherin in desmosome).
