CHEM 212 Lecture Notes - Lecture 4: Rate-Determining Step, Elimination Reaction, Lg Corporation
27 Feb 2019
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Document Summary
Halogens (halogen anions) make medium strength nucleophiles as down the group they are too big and up the group too electronegative. This only applies for cl,br and i. f anion is a very weak nu as even though it is negatively charged it is very electronegative. Neutral nucleophiles are weak in reactivity as they need some energy to let go of that exra pair of electrons. The lewis base here is a base (lewis base can be both a nucleophile or a base, a base is used in elimination reaction) Two types of elemination reaction: dehydrohalogenation and dehydration. The electrophile here is not the carbocation (as in sn reactions) instead it is an h attached to the c that is adjacent to the halide or the leaving group. Base strengths: strong acids have weak conjugate bases. Strong basaes have weak conjugate acids (smaller ka and large pka) Just like sn reactions, heterolytic bonds are formed/made.
