CHEM 183 Lecture Notes - Lecture 1: Thomas Quasthoff, Multiple Myeloma, Multiple Sclerosis

• School: McGill University
• Department: Chemistry
• Course: CHEM 183
• Professor: Ariel Fenster

Document Summary

Potent teratogen = birth defects = shortening of arms and legs. Highlights the importance of drug testing (was an effective anti-nausea agent) Mainly in europe, some in canada, a few in the usa. Dr frances kelsey was in charge of coordinating testing for fda and decided there wasn"t enough testing and she shut it down and it was not available in the usa for anti nausea purposes. Leprosy treatment as well as certain cancers. Durham humphrey 1951 amendment to the 1938 fda act. Before 1951, prescription status was only for narcotics and cocaine. Timeline: identify targets, find leads (molecules have to be effective in some kind of way), develop leads, pick a development candidate, make drug, formulate, toxicology, clinical trials, regulatory approval. Research must prevent poor candidates from going to development (which starts at the making of the drug stage and is where the costs really come in) Relatively level every year but r&d expenditures skyrocketing.