CHEM 183 Lecture Notes - Lecture 3: Paul Erlich, Dye, Gram-Negative Bacteria

• School: McGill University
• Department: Chemistry
• Course: CHEM 183
• Professor: David Noble Harpp

Document Summary

It is an antibacterial agent produced by a living organism: today, it"s just an antibacterial agent, only effective with bacterial origin, plague, cholera, tuberculosis, not effective against viral origins (common cold, flu, poliomyelitis, hiv, aids) Leading causes of death in canada: 1990, pneumonia and tuberculoss, today, cancer (30%, heart disease (22%) Gram negative: didn"t take the dye: difference between grams has to do with cell wall structure. Gram positive = thick polysaharide cell walls. Gram negative = thin polysaharide cell walls: paul erlich, death causes in france. Tuberculosis: 150 000 (rare today because there"s drugs now) Cancer: 40 000: had an idea since the bacteria can pick up the dye, would it be possible to beat the bacteria with it. 9 stomach chemistry / antibiotics: used trypan red. Found it was effective in sleeping sickness (caused by tse-tse. Nitrogen is in the same column as arsenic of the periodic table and arsenic is toxic.