CHEM 181 Lecture Notes - Lecture 6: Siraitia Grosvenorii, Chlorine, Nutrasweet

• School: McGill University
• Department: Chemistry
• Course: CHEM 181
• Professor: Ariel Fenster

Document Summary

Increased incidence of bladder cancer among male rats fed high lifetime amounts of saccharin, & whose parents has also been fed high lifetime amounts of. Hazard (toxicity) : ex: lions present a hazard no matter where they are found, but high-risk in wild, and low-risk in zoos, similarly, not all species are susceptible to lions! Video 5 aspartame: accidently discovered by james schlatter (1965, made from aspartic acid & phenylalanine, aspartame is part of methyl ester group, when digested by body, releases methanol, 200x as sweet as sugar, 4 cal/g. Problems: headaches, dizziness, fatigue, mood changes none confirmed, could be caused by release of brain chemicals when aspartame breaks down. Leads to adi (acceptable daily intake) for humans: 40 mg/kg. 70 kg man would have to drink ~20 cans to reach adi & ~1600 cans to reach noael: some studies indicate aspartame could cause cancer in test animals, ramazzini institute: 1800 rats fed various amounts of aspartame over lifetime.