BIOL 300 Lecture Notes - Lecture 22: Endonuclease, Protein Folding, Cell Surface Receptor
5 Mar 2018
School
Department
Course
Professor
Document Summary
It phosphorylates (since it is a kinase) s6k which is a protein that makes the ribosome more efficient. It upregulates ribosome biogenesis (enables the making of more ribosomes) If there is a lot of food available, the mitochondria runs at full speed and there is a lot of atp available in the cell and very little. The more 4e-bp is phosphorylated, the less it can bind to eif4e: now eif4g can bind and help assemble the pre-initiation complex, when 4e-bp is hypophosphorylated, it can bind to eif4e and shut down translation. Unfolded protein response (upr: the unfolded protein response (upr) matches the ability of the endoplasmic reticulum (er) to fold and process client proteins (capacity) with the load of client proteins facing the organelle (demand). The demand is set by the physiological agenda of the cell and may be influenced by mutations that affect client protein"s ability to fold.
