BIOL 300 Lecture Notes - Lecture 9: Nucleosome, Critical Role, Lamin

• School: McGill University
• Department: Biology
• Course: BIOL 300
• Professor: Frieder Schoeck

Document Summary

Lecture 9 aspects of eukaryotic gene regulations that can affect the expression of neighboring. 22 multiple choice questions and 5 short answer. Enhancers and silencers genes: by definition, enhancers can act at long distances; can be downstream or upstream, need a mechanism that makes sure the enhancers/silencers only affect the genes they are. Insulators: dna sequences that prevent eukaryotic gene regulatory proteins from influencing distant genes, also known as boundary elements , bind specialized proteins that mediate those effects, can think of it as a border between countries. Insulators are placed at the borders of the domain of actively transcribed chromatin to ensure that things within the insulators work together but they do not interact with things outside of the borders. If insulator is placed between gene a and the enhancer, the enhancer cannot activate gene a: however the enhancer can affect gene b. In pairs can create independent functional domain by blocking positive or negative effects of surrounding chromatin.