BIOL 201 Lecture Notes - Lecture 15: Skeletal Muscle, Immunoglobulin Light Chain, Myocyte
20 Feb 2018
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Document Summary
There are different classes of myocin: ex: myocin ii in skeletal muscles, they convert chemical energy from atp to mechanical work, different myocins, different functions. Myosins have head, neck and tail domains with distinct functions. Skeletal muscle is made of thick filaments and thin filaments: thick filaments: myosin-ii which homodimerizes and forms a bipolar bundle. Myosin is a protein complex with 6 subunits. 2 heavy chains: high molecular weight, have a: Acts as a lever arm for the motor domain of the myosin. Intertwine, putting head domains close to one another. 4 light chains: smaller molecular weight, associate with heavy, 2 types: Myosin form bundles that pull actin filaments inward. Interdigitation of actin filaments with the myosin is the main mechanism behind muscle contraction: to generate muscle force, muscle made these processes extremely parallel. Muscle is made of parallel muscle fiber bundles. Bundles are made of fibers: made of multinucleated (fused) muscle cells.
