BIOL 200 Lecture Notes - Lecture 44: Base Pair, Zygote, Long Non-Coding Rna
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Hsp90: (cid:120) heat shock protein (hsp) levels increase rapidly in response to heat shock and other cellular stresses (cid:120) Interacts with client protein and takes it into the interior: closed state, forms a favourable environment for the polypeptide to fold up in a manner, dimers then change conformation and open up, release protein, adp dissociated. Groel acts as a bacterial chaperonin to correctly fold proteins (cid:120) chaperonins are large macromolecular machines devoted to folding (cid:120) tric in humans (little understood). These are associated with neuronal cell death: may be due to tangles in fibres. Protein folding and other pathologies (cid:120) kuru was the feared disease of many members of the fore people a cannibalistic tribe of new guinea (cid:120) the laughing death because of uncontrolled outbursts in later stages of the illness. This thus causes infection in a dominant manner.
