BIOL 200 Lecture Notes - Lecture 43: Histone H2B, Isotopic Labeling, Ern1
Document Summary
Lecture 27 protein folding and quality control mrnas that are actively translated are more stable (cid:120) formation of circles protect poly a tail from de-adenylation, exonucleolytic and endonucleolytic activity, and de- capping (cid:120) Important as a quality control mechanism (cid:198) pioneering round of translation-quality control (cid:131) giant processing machines that thread through canal in the mrna (cid:131) proteins in the way get kicked off (cid:120) In a wild type mrna, the ribosomes read through the mrna, kick off associated proteins, and come to a termination signal (cid:120) the proteins that get kicked off are important quality- control proteins put on in the nucleus (cid:120) Hsp90: (cid:120) heat shock protein (hsp) levels increase rapidly in response to heat shock and other cellular stresses (cid:120) Interacts with client protein and takes it into the interior: closed state, forms a favourable environment for the polypeptide to fold up in a manner, dimers then change conformation and open up, release protein, adp dissociated.
