BIOL 115 Lecture Notes - Lecture 11: Lipid Bilayer, Proteasome, Membrane Structure
25 Jun 2016
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Document Summary
Denaturation/renaturation: denaturation the loss of a proteins norman 3d structure and function, renaturization refolding, this occurs in the test tube. Protein turnover (breakdown and resynthesis) occurs constantly: chaperones are specialized proteins that help keep other proteins from interacting inappropriately with each other (temporarily isolate newly synthesized proteins so they can fold) Phospholipid bilayer separates two aqueous regions: has cholesterol in it (which has a rigid ring structure) to adjust the fluidity (makes it more solid) It is energetic favorable for bilayers to seal/form an enclosed sapace. Peripheral membrane proteins: lack hydrophobic regions, are not embedded in the bilayer, are convalently attached to lipids or bind noncovalently to other transmembrane proteins. 1 diffusion diffusion the passive mixing of substances resulting in transport along a concentration gradient occurs due to brownian motion random motion diffusion rates determined by distance, temperature, size of molecule, concentration gradient. Some small uncharged polar molecules: no large polar molecules, ions.
