PHYL 4504 Lecture Notes - Lecture 22: Polycyclic Aromatic Hydrocarbon, Epidermal Growth Factor Receptor, Braf (Gene)
6 Jan 2021
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Phyl 4504 lecture 22 november 30, 2020 cellular pathophysiology of lung cancers. Objectives: describe three risk factors for lung cancers, recognize three hallmarks of cancer, understand egfr signaling pathways and how signaling can be hijacked at every point of the. By the end of the lecture, you should be able to answer the following questions: name the leading risk factor for the development of lung cancers. Payloads in adc are cytotoxic compounds covalently bound to recombinant humanized monoclonal antibodies (mabs) whose purpose is to kill tumor cells. Classification of lung cancers: non-small cell lung cancer (nsclc) (85% of total lung cancer cases, adenocarcinoma (40% total lung cancer cases) most common among non-smokers, histologically, you might see mucin deposition. Named so due to high nucleus/cytoplasm ratio: highly aggressive and metastatic, hyperactive malignant growth, highly associated with smoking (95% patients have history of smoking), on the other hand, it is highly responsive to chemotherapy/radiation (targeting rapidly proliferating cells).
