PHYL 1010X Lecture Notes - Lecture 7: Nernst Equation, Goldman Equation, Membrane Potential
22 Sep 2018
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Body total is in eq but body compartments are in disequilibrium. 1 unmatched neg. in icf and 1 unmatched pos. in ecf- makes electrical disequilibrium when charges outside don"t match charges inside. [k+ ] higher in cell, [na-] lower in cell. Concentration gradient pulls k+ out while electrical gradient pulls them in the cell. The more charges the more attraction and force (potential) Calc using nernst equation (don"t need to know calculations) Permeability depend on the amount of open potassium channels and open sodium channels. Calc using goldman equation (don"t need to know calculations) Membrane potential is not the same as sodium or potassium, they can leak down their concentration gradient- that is why sodium potassium pump is necessary. Hyperpolarized- more neg. than resting value(-70), more neg.
