PATH 3000 Lecture Notes - Lecture 8: Dense Granule, Vasospasm, Hemostasis
21 Feb 2020
School
Department
Course
Professor
Document Summary
Path 3000 lecture 8 january 24, 2020 bleeding cell disorders. The blood vessel is lined with endothelial cells. For hemostasis purposes, the endothelial cells which forms the vessel wall keeps subendothelial collagen covered. Collagen is a factor underneath the vessel wall and is important is triggering the clotting factor. In this example, there is enough tissue damage to cause a break in the vessel wall. Exposure to the collagen in the subendothelial layer attracts platelets and binds and activate platelets. Platelet plug is also called primary hemostasis but is not a strong or long-lived clot mediated by the platelets. The release of prothrombin activator (tissue factor), which is a protein in the coagulation cascade, is released from damage tissues and activates the clotting cascade. There is conversion of fibrinogen to fibrin, which is a criss-cross network to aid with a clot (holds platelets and proteins together). Rbcs contribute to the stability and longevity of the clot as well.
