NURS 2050 Lecture Notes - Lecture 10: Fatty Liver, Integrase, Androgen Replacement Therapy
19 Jan 2017
School
Department
Course
Professor
Document Summary
Virus particle with a nucleic acid and a protein coat. Viruses require a living cell to replicate. Has the ability to kill or modify cellular functions protein synthesis. Nucleic acid must be uncoated to gain access to cellular machinery of the cell. Penetration with entry of the nucleic acid into the cell. Early expression of virus genes (positive rna, transcription and or translation) Exit from the cell: have you looked up the drugs acyclovir and ganciclovir for hiv retinitis? (mechanisms, key side effects, drug interactions) Acyclovir: type: antiviral, mechanism: interferes with dna synthesis, dosage path: po, poor absorption, adverse effects: seizures, renal failure, steve-johnsons syndrome, ttpus, concerning drug interactions: probenecid, theophylline, phenytoin. Inhibits dna polymerase: adverse effects: seizures, gi bleeding, concerning drug interactions: increased toxicity with probenecid, kidney toxicity with other nephrotoxic drugs cyclosporine. Art initial cd4 count is above 500cells/mm3. Medications: abacavir, didanosine, ribavarin, tenofovir, competitively inhibits hiv reverse transcriptase and termination of the dna chain.
