NURS 2050 Lecture Notes - Lecture 2: Complement Membrane Attack Complex, Vascular Permeability, Mast Cell
19 Jan 2017
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Document Summary
Tissue damage causes release of vasoactive and chemotactic factors that trigger a local increase in blood flow and capillary permeability. Permeable capillaries allow an influx of fluid(exudate) and cells. Phagocytes migrate to site of inflammation (chemotaxin) Will release chemokines and cytokines which are messenger proteins. Cytokines activate the tnpalpha (tumour necrosis p alpha) + il-1-6 interleukin. Pamps and damps stimulate mast cells to release histamines. Will release histamine cause vasodilation increased capillary permeability = white platelets and stuff and go to the damaged area. There are platelets, rbc and wbc that need to get to the injury. When the histamines (released by mast cell) dilate the vessels so that the capillaries. Are more permeable to allow plateles, rbc and wbc to go there. You feel heat when there is swelling because. Proteins pulls fluid (platelets, rbc, wbc) causes swelling. Neutrophils will squeeze through opening of capillary diapedsis: these neutrophils help. Monocytes in the capillary turn into macrophages in the tissue.
