NESC 3180 Lecture : October 10th, 2012.docx

• School: Dalhousie University
• Department: Neuroscience
• Course: NESC 3180
• Professor: Shelly Adamo

Document Summary

Because glucocorticoids activate bzlf1: responsible for inducing lytic replication of ebv. Glucocorticoids can induce the latent ebv genome to lytically replicate through the induction of the ebv immediate early gene bzlf1. Increasing concentrations of hydrocortisone or dexamethasone on daudi cells; dex induction compared to when used with gr; pcr and mrna analysis of gene products. Both hydrocortisone and dexamethasone upregulate transcription of bzlf1; gr inhibit dex upregulation. Glucocorticoids can induce the ebv genome to replicate through transcription of the bzlf1 gene;