NESC 2570 Lecture Notes - Cytoskeleton, Proprioception, Cochlear Duct
26 Nov 2012
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Very deep in the dermis, onion structure, dampens signal to nerve, detects vibration. Massively adapting, responds only at the onset of stimulation: meissner"s corpuscle. Just below epidermis, pressure, vibration, stretch (stroking: ruffini"s corpuscle. Each hair has a hair receptor: free nerve ending wrapped around follicle. Had a lot of anchorin: have motor proteins attached, bound to cytoskeleton. Have a very large, mylenated axon --> very fast response. Can tell how much muscle length has changed. Golgi tendon organs: at interface where muscle attaches to a tendon. Give rise to opposite pull on muscles. Pain, temperature, itch: slow conducting, small, unmylenated. Capsacian can cause response: comes from hot peppers, makes some trp channels open. Activated by capsacian: nonspecific cation channels. Transduction: occurs on basilar membrane by hair cells. Tectorial membrane: above basilar, hair cells project up into it. Are little motors that can move the tectorial membrane: movement of the cillia back and forth are what cause signals to be sent.
