MICI 4218 Lecture Notes - Lecture 32: Human Granulocytic Anaplasmosis, Rickettsia, Scrub Typhus
12 May 2021
School
Department
Course
Professor
Document Summary
Mici 4218 lecture 32 april 5, 2021 tick-borne infections. Proteins on the bacteria"s surface can polymerize actin. When the actin is polymerizing, it pushes the bacteria throughout the cell. The bacteria can also push itself into another cell to spread from cell to cell (systemic spread). Listeria monocytogenes, shigella spp. and rickettsia rickettsii are three examples that display actin-based motility. Rickettsial pathogens: historically, other pathogens were thought to be rickettsia (from old textbooks, legionella pneumophila (legionnaires" disease) intracellular, fastidious. *- spotted fevers and typhus: orientia tsutsugamushi* - scrub typhus, others, ehrlichia human monocytic ehrlichiosis, anaplasma human granulocytic anaplasmosis. This is a phylogenetic tree showing where rickettsial pathogens are found. Rickettsial diseases are zoonoses so they are transmitted through animals, but they are indirect, meaning that they require vectors. Arthropods are grouped in two subsets: arachnids and insects. Rickettsial diseases - clinical manifestations: rickettsia produces a vasculitis throughout the body.
