MICI 4218 Lecture Notes - Lecture 2: Antimicrobial Resistance, Bactericide, 1918 Flu Pandemic
25 Jan 2021
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Mici 4218 lecture 2 january 8, 2021 antimicrobials: principles of use. Objectives: definitions and principles of antimicrobial therapy, appropriate use and selection, therapeutic index, empiric management, antimicrobial resistance and its implications, antimicrobial stewardship role of physicians. Human life expectancy is increasing upwards, obviously due to a number of reasons increased sanitation, vaccines, and the use of antibiotics almost doubled the expectancy. The dip in 1918 is the spanish flu. Principles / definitions: spectrum of activity, broad vs. narrow (ex. If the drug is bactericidal, it would kill the organism: time dependent killing (tdk) vs. What is important is the ability to maintain the level of drug above the mic of the organism for as long as you can (exposure time dependent) After the addition of antimicrobial into the culture and stasis follows, the drug is bacteriostatic. If the antibiotic is taken away, the organism resumes growth.
