MICI 2100 Lecture Notes - Lecture 18: Orthomyxoviridae, Virus, Poliovirus
26 Nov 2018
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Mici 2100 lecture 18 november 20, 2018 virus assembly and egress. The virus needs to get into the cell and replicates its genomes and make virion proteins. The virion proteins need to be assembled and the virion needs to escape somehow to spread and infect other cells. All viruses follow common steps in a single replication cycle. Aputtgar: attachment, penetration, uncoating, transcription, translation, genome replication, assembly, release. Note: all viruses are too large to diffuse across the plasma membrane so they need to get in and out using specific cellular mechanisms. Overview: assembly and release (egress: virus assembly from pre-formed components, egress (exit) from the host cell. Each protein of the virus needs to be put together. First, the proteins need to be made, and then assembled to make a virion, an infectious particle. It then needs to exit from the host cells.
