BIOL 2020 Lecture Notes - Lecture 16: Tubulin, Microtubule, Microfilament

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Biol 2020 lecture 16 march 1, 2019 section 5: cytoskeleton and cell motility. The cytoskeleton and cell motility: microtubules, microfilaments. General features: cytoskeletal elements are not membrane-bound (surrounded by membranes), all cytoskeletal elements are polymers, made up of individual monomeric proteins, microtubules are made up polymers of tubulin, microfilaments are made up polymers of actin. There is a whole bunch of proteins that are assemble to make this type of filaments: all monomeric linkages are non-covalent linkages, which are weak. They are therefore dynamic elements, our cell skeleton are always changing, unlike our bone skeleton. (ex. Cytoskeleton functions: structure (giving the cell its shape) and movement (moving things around in the inside of the cell or moving the entire cell -> cell locomotion). The subunit can hydrolyse the gtp to gdp. But on , it is always a gtp: microtubules: protofilaments and associated proteins visible. Microtubules are about 25nm in diameter, which is huge.

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