BIOC 4403 Lecture Notes - Lecture 24: Ribosomal Rna, Cytosol, Spliceosome
18 Apr 2016
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4403 ii l4 - alternative splicing ii: three main types of alternative pre- mrna splicing, exon skipping, alternative exon size. Intron retention: exon skipping, alternative exon size, intron retention whole exons are skipped or either spliced into mrna exons are shorter or longer depending on the different splice sites used. Sam68 protein binds to an rna sequence in the large subunit rrna and is a component of the ribosome. When rrna binding sites are saturated, excess rpl30 binds to so rna target sequence in the first exon/intron junction of the pre-mrna and blocks pre-mrna splicing. As events occur specifically in neuronal development (many as patterns are unique to humans) Generally it is the combination of active splicing proteins available when and where transcription occurs: what determines the outcome of rna splicing of a particular gene in a particular moment, splicing. Splicing reactions are spatially localized localization: nuclear and splicing proteins.
