BIOC 3300 Lecture Notes - Lecture 15: Hmg-Coa Reductase, Dimethylallyl Pyrophosphate, Isoprene
4 Apr 2016
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Forms cholesterol rich, small dynamic lateral membrane domains together with sphingolipids. Precursor of steroid hormones, vitamin d, bile acids. Glucocorticoids: what enzymes convert acetyl-coa into hmg- Hmg-coa synthase (condenses another acetyl-coa with acetoacetyl-coa, forming hmg- Nadph: what is the rate limiting step in cholesterol biosynthesis, what creates isoprene units that are used in cholesterol biosynthesis, what is the form of an activated isoprene unit? conversion of hmg-coa to mevalonate. In an energy surplus/demand, what is acetyl-coa used for? surplus: synthesis demand: citric acid cycle. Pyruvate (cytosol -> mitochondria: what enzyme generates cytosolic acetyl-coa, and what is its substrate, what are the products of the tricarboxylate transport system? citrate lyase, from citrate (uses atp) acetyl-coa. Makes protein much more hydrophobic, tethers the protein to a membrane squalene synthesis (6 isoprene units condense: what enzyme catalyzes. Oxidosqualene cyclase the formation of the sterol ring system: what two substrates are. Class ii (prokaryotes: what is the structure of.
