PSYC 441 Lecture Notes - Lecture 12: Hypokinesia, Basal Ganglia, Tardive Dyskinesia
10 Nov 2017
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Lecture 12 antipsychotic drug tx in sz: relationship of meso-striatal da to symptoms, study (laruelle, 1999), procedure: People with sz given small doses of amphetamine: results: Greater da reactivity related to increases in positive symptoms. Greater da reactivity related to decreases in negative symptoms: antipsychotic medicine tx in sz, recall, medi(cid:272)atio(cid:374)s treat sy(cid:373)pto(cid:373)s, (cid:271)ut do(cid:374)"t (cid:272)ure the disease, which medications, first generation (chlorpromazine): Direct effect on d2 receptors: second generations (everything else): First discovered by accident, then developed through research. Indirect effects on d2, mostly through effects on serotonin and gaba systems. Despite i(cid:374)itial high hopes, se(cid:272)o(cid:374)d ge(cid:374)eratio(cid:374) a(cid:374)tipsy(cid:272)hoti(cid:272)s do(cid:374)"t appear to be more effective (especially for negative symptoms): However, we so see a reduced risk of extra-pyramidal side-effects and tardive dyskinesia (i. e. have a less hurtful side-effect profile): first vs. second: No evidence that one medication (or variation) is better:
