CHEM 271 Lecture Notes - Lecture 21: Oxidative Phosphorylation, Reduction Potential, Electron Transport Chain
18 Dec 2015
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Apparatus for the measurement of the standard oxidation reduction potential of a redox couple. Electrons, but not x or x2, can flow through the agar bridge. Thus, the oxidation of fuels and the phosphorylation of adp are coupled by a proton gradient across the inner mitochondrial membrane (figure 18. 1). Electrons flow from nadh and fadh2 through four protein complexes to reduce oxygen to water. Three of the complexes pump protons from the mitochondrial matrix to the exterior of the mitochondria. The protons return to the matrix by flowing through another protein complex, atp synthase, powering the synthesis of atp. O2through a chain of three large protein complexes called nadh-q oxidoreductase, q-cytochromec oxidoreductase, and cytochromec oxidase(figure 18. 6 and table electron flow within these transmembrane complexes leads to the transport of protons across the inner mitochondrial membrane. A fourth large protein complex, called succinate-q reductase, contains the succinate dehydrogenase that generates fadh2in the citric acid cycle.
