CHEM 271 Lecture Notes - Lecture 12: Cytidine Triphosphate, Uridine Triphosphate, Allosteric Regulation
13 Dec 2016
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Document Summary
You should know the five types of regulatory strategies: allosteric control: uses allosteric proteins that have distinct regulatory sites and multiple functional sites that bind to small signal molecules, which control the activity of the protein. They"re homologous enzymes within a single organism that catalyze same reaction but differ in km and vmax. Ie: differences in stages of development or tissue type need different isozymes. Ie: blood clotting: controlling the amount of enzyme present: enzyme activity regulated by adjusting the amount of enzyme present. You should know how aspartate transcarbamoylase (atcase) is regulated. It catalyzes the first step in biosynthesis of pyrimidines. Consists of 10 steps that yield pyrimidine nucleotides uridine triphosphate (utp) and cytidine triphosphate (ctp). It is inhibited by ctp so it starts off fast when there is no ctp but slows once the concentration increases. Ctp binds to a site that isn"t the active site, which are called allosteric or regulatory sites.
