BIOL 467 Lecture 6: BIOL 467 - lecture 6 - 29-09-2017
Document Summary
Work opposite of mitogens preventing cell cycle entry do this because they active smads which can regulate the promoters & thus regulate the exprsesionof myc and. Myc key transcriptional regulators of cyclin d downregulating myk cyclin d not expressed. At the same time it can help promote via miz1 the expression of ink4 (inhibitor of cdk 4 or 6) These two things can ensure that there"s a block of cell cycle entry in the presence of these anti-mitogens. Mutations in tgfb related gene in c. elegans gives rise to worms of varying sizes. If you have a loss of function mutation in tgfb or one of those pathways components would look like a because you have less growth (they"re proliferating but not growing) Anti-mitogens = growth regulator, by inhibiting cell cycle they"re allowing cells to grow. Cell cycle entry is also controlled by prb. Prb binds and inhibits e2f in g0 and early g1.
