BIOL 461 Lecture Notes - Lecture 11: Exon Skipping, Testis Determining Factor, Gonad
24 Apr 2018
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Dosage compensation one essential function for viability in sex determination. Fe(cid:373)ales of da (cid:373)others (cid:449)ho do(cid:374)"t get this ge(cid:374)e produ(cid:272)t i(cid:374) the egg will die, but males are just fine. Males with m1 die even if their mother is heterozygous or homozygous for da. Sxl key master regulatory switch in gender determination in drosophila sxl1 acts zygotically if the zygote gets it the females are safe and the males are dead. Sex lethal wt daughters die if their mothers are da mutant at the restrictive temperature at 25 c. The sons that get sxlm1 die, independent of da. They use the gold standard of a duplication and a deficiency as a gof and lof to see how sxl can work. If you reduce the da function, by having a da homozygous mutant mother at the permissive so some daughters will live but not all of them.
