BIOL 461 Lecture Notes - Lecture 16: Biomed Central, Gene Expression, Allele
24 Apr 2018
School
Department
Course
Professor
Document Summary
Biol 461 lecture 16 week 9 wednesday. Key question of the paper: what is the function of lin-12 in cell-cell signaling in development. How cells signal to determine cell fate. We know that lin12 is involved with the signal. Look at lin-12 mutants (null that"s re(cid:272)essi(cid:448)e a(cid:374)d gof that"s do(cid:373)i(cid:374)a(cid:374)t(cid:895: lin12 on: 2 vu, lin12 off: 2 ac. Therefore its required for the signal, its not just responsible for one fate or the other. Whether lin-12 codes the receptor or the signal, if the (cid:449)hole a(cid:374)i(cid:373)al is (cid:373)uta(cid:374)t (cid:455)ou"ll always get ac cells. Make a mosaic: one cell is mutant and the other cell is wt. If lin12 is the signal, the mutant cell will not be able to make the signal but it can receive, so it will be vu. (wt would be. If lin12 is the receptor* mutant can do the signal but it can"t receive, the lin12 mutant cell will always be ac.
