BIOL 371 Lecture Notes - Lecture 19: Collagen, Botulinum Toxin, Cell Membrane
Document Summary
Miniquiz questions & asnwers chapter 25. 1-25. 8 (lecture 19) Adherence is the enhanced ability of microbes to attach to host tissues. Describe the molecules or structures that facilitate pathogen adherence to host tissues. Capsules: capsule is both sticky and contains specific receptors to facilitate attachment on host tissues adhesins - glycoproteins or lipoproteins found on the pathogen"s surface that enabled it to bind to host cells slime layers. Colonization typically begins in the mucous membranes (epithelial cells that interface with external environment) Virulence factor is a toxic or destructive substance produced by the pathogen that directly or indirectly enhances invasiveness and host damage by facilitating and promoting infection. Thought to occur because nonvirulent or weakly virulent mutants grow faster than virulent strains where virulence has no selective advantage. Several genes that direct invasion are clustered together on the chromosome as pathogenicity islands (spi1 and spi2) (lots of horizontal transmissions) Another salmonella pathogenicity island contains genes that promote a more systemic disease.
