PSYC 2307 Lecture Notes - Lecture 3: Lethal Dose, Analgesic, Cholinergic
23 Jun 2020
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Most of these adrenergic agents are site specific (e. g. , Metoprolol is beta1 specific): cns stimulants act by increasing the available amount of the neurotransmitter norepinephrine which will increase cellular impulse transmission. Inhibits: agonists, two types, direct binding agonists: drugs that directly bind to the postsynaptic receptors- replace the neurotransmitter. Examples of direct-binding agonist drugs include dopamine, apomorphine, and nicotine. A common example of a drug belonging to this category is atropine. Indirect-acting antagonist -- inhibit release or production of nt. Locus of effect: presynaptic membrane release nt (e. g. , acetylcholine)into the synaptic cleft in sensory and motor neurons: symptoms convulsion, way #5: drug inhibits release of nt, net effect: antagonist. Locus of effect: on the postynaptic receptors increases the levels of several neurotransmitters: way #7: drug blocks postsynaptic recepors, net effect: antagonist, example drug: curare --reversibly inhibits the nicotinic acetylcholine receptor, a.
