NEUR 4306 Lecture Notes - Lecture 10: Neurotransmitter, Nicotine Dependence, Glossary Of British Ordnance Terms
16 Jul 2020
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If the dose is too high they will find it aversive (nausea and lightheadedness) Interestingly, this phasic firing is due to the action of nicotine on. Vta: nicotine dependence depends on glutamatergic inputs, this is the indirect action of nicotine. If you have too much gaba input is decreases the rewarding properties of nicotine (you are shutting down the vta: however, note that nicotine excites nachrs (alpha4 beta 2 receptors) on. Gaba-releasing terminals leads to release of gaba, which inhibits da what"s going on: seems to be critical for phasic / burst firing of the vta da neuron! (see: Implant is subcutaneously, slowly secretes the substance: administered mecamylamine, nachr antagonist, mecamylamine is a nicotinic antagonist, assessed reward thresholds. Implications: suggests crf signalling in cea must at least partially mediate the negative affect during precipitated nicotine withdrawal: blocking crf makes animals feel less crappy (les in withdrawal)
