NEUR 4306 Lecture Notes - Lecture 3: Nucleus Accumbens, Dopaminergic Pathways, Basolateral Amygdala
16 Jul 2020
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Document Summary
Involved in hormone secretion: specially lactation, focus: mesocortico-limbic dopamine system, cell bodies in vta . Block inhibotry control of the vta: nicotine: stimulates nicotinic cholinergic receptors in the vta, nacc, and amg, cannabinoids: stimulate cannabinoid receptors in all regions; enhance da release in. Inhibits camp signaling: not implicated in reward, review, vta neurosn help quiet, when a certain amount of disinihibition occurs, when we have burst firing it binds to d1 receptors, this is wha causes reward, methods minute! How pet & raclopride works: raclopride is a selective antagonist at d2 receptors, occupies the site, sits on it and doesn"t allow anything else ot brind to it, radioisotope that can be radiolabeled for pet. It can be radiolabeled with radioisotopes, e. g. , 3h or 11c, and used as a tracer for in vivo. Pet: radioactive raclopride is injectied, when administered, radioactive raclopride will accumulate in dopamine rich areas, e. g,. Striatum: competes for receptor occupancy with released da.
