NEUR 3502 Lecture Notes - Lecture 19: Mitochondrial Matrix, Adenosine Triphosphate, Intermembrane Space
15 Jul 2020
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Document Summary
Inter-membrane space: mitochondrial matrix, contains mitochondrial dna (mtdna, mitochondrial function is essential for energy hungry neurons. In the way in which the neuron is interacting with muschles in the body and normally end up with seeing muscle atrophy. Etc: cytochrome c oxidase is complex iv of the mitochondria respiratory chain, the complex is mutated when producing cox and its correlation with. Leigh disease: are expected to take a system when it"s not working properly and relate it to a neurodevelopmental disorder, all of the complexes (chain reaction) are required for the production of. Etc is a reactive oygen species (doesn"t further the processing to water)) > Neurons cannot communicate : neurodevelopment affected (neurons need to communicate in order to facilitate proper trajectory, and if lacking it can throw off neurodevelopmental pattern) Infant to childhood onset: diagnosis and treatment, understanding mitochondrial diseases limited by, broad spectrum of disorder. Little information on pathological mechanisms: goal of current treatment.
